Wolfgang Schober

GT-Toxicology Preis 2007 für Wolfgang Schober

Organic extracts of urban aerosol (< PM2.5) enhance rBet v 1-induced upregulation of CD63 in basophils from birch pollen-allergic individuals

Epidemiological studies have linked the high prevalence rates of IgE-mediated allergic diseases to an increase in exposure to traffic-related air pollutants such as diesel exhaust particles (DEPs). There is growing experimental evidence that organic compounds of DEPs, predominantly polycyclic aromatic hydrocarbons (PAHs), participate in the development and maintenance of allergic airway diseases. In this study we investigated the impact of organic extracts of urban aerosol (AERex) containing various PAH concentrations on the activation of human basophils. Whole blood samples from six birch pollen–allergic and five control subjects were repeatedly incubated in the presence of AERex with or without recombinant Bet v 1 (rBet v 1). Basophils were analyzed for CD63 expression as a measure of basophil activation by using multiparameter flow cytometry. Basophils, when exposed in vitro to AERex and rBet v 1, expressed CD63 significantly more than with antigen activation alone. AERex synergized with rBet v 1 in a dose-dependent manner, but did not activate basophils from nonallergic donors. AERex effect on CD63 upregulation was found in blood samples of all patients and did not occur in the absence of rBet v 1. Strongest basophil activation was monitored upon stimulation with AERex comprising the highest PAH content. The capability of AERex to increase activation of basophils from birch pollen–allergic subjects at ambient concentrations suggests an important role of organic compounds of airborne particles in the aggravation of IgE-mediated allergic diseases. This could be a new aspect of regulation of unspecific promoting stimuli in clinical manifestation of allergic inflammation.

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Gemeinsam gestiftet von den Herausgebern des Buches "Toxicology", Herr Prof. Siegried Schäfer und Herr Prof. Holger Barth.

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Poster der GT auf der SOT-Tagung 2018

Society of Toxicology 57th Annual Meeting and ToxExpo, March 11–15, 2018, in San Antonio, Texas
Poster

Sonderheft "Human Biomonitoring 2016" erschienen

Das Sonderheft "Human Biomonitoring 2016", Volume 220/2 Part A der Zeitschrift International Journal of Hygiene and Environmental Health ist erschienen. Insgesamt 34 Beiträge stellen den aktuellen Stand des weltweiten Human-Biomonitorings (HBM) dar.

Das Sonderheft wurde im Nachgang zur 2. Internationalen Human-Biomonitoring Konferenz, Berlin 2016, zusammengestellt, die unter dem Motto "Wissenschaft und Politik für eine gesunde Zukunft" gemeinsam vom Umweltbundesamt und dem Bundesministerium für Umwelt, Naturschutz, Bau und Reaktorsicherheit durchgeführt wurde.

Alle Artikel sind ein Jahr im Open-Access online frei verfügbar: www.sciencedirect.com/...

Pressemitteilung

Toxikologen warnen: Gesundheits- und Umweltschutz in Gefahr; Fachgesellschaft beklagt Mangel an Ausbildungsplätzen
PDToxGes2015.pdf

Positionspapier des Arbeitskreises zum Humanbiomonitoring


Humanbiomonitoring.pdf